Effects of Korean white ginseng extracts on obesity in highfat diet-induced obese mice

Korean ginseng (Panax ginseng CA.Meyer) is purchased from Geumsan Undried Ginseng Center (Geumsan, Korea). The true root is panax ginseng type, 4–6 years old, grown in Geumsan County, Korea. Ginseng is used in herbal medicine as A general tonic to promote health in Asian countries including Korea, China, and Japan for 1,000 years.

Ginseng is available its description according to its taste environment, soil conditions, and harvest time. These differences can lead to changes in bioactive compounds in ginseng. The medicinal properties of ginseng are derived from ginsenosides, also called steroid saponins, in ginseng extract. No pharmacological effects of ginseng extract and Ginsenosides are reported in immunology, cancer, arteriosclerosis, high blood pressure, and diabetes.

Effects of KGE on the expression of lipogenesis genes and proteins

To investigate whether the anti-obesity effect of KGE associated with decreased lipogenesis in WAT, and lipogenesis is related to mRNA and protein levels and WAT was analyzed by real-time PCR as well sunset spot. As shown in fig. 3a, mRNA level of SREBP-1c, LPL and DGAT1 in WAT have been increased in the HFD group compared to the control group LFD group (p\0.05). However, the expression levels of these genes in HFD? 1.6KGE one is was significantly reduced compared to the HFD group (p\0.05). Although the mRNA level of PPARc2 and FAS was not significantly different between LFD group and HFD group, they are very reduced on HFD? 1.6KGE group compares HFD group (p\0.01). The mRNA level of SREBP-1c was significantly reduced, and HDF? 0.8KGE group compared to HFD group (p\0.05). However, the mRNA level of SCD-1 and HFD? One 1.6KGE in mRNA Levels of LPL, FAS and DGAT1 are usually low HDF and? 0.8KGE group compared to HFD one, the difference is not significant. PPARc2 Protein expression levels in WAT showed a trend reduction in HFD? 1.6KGE compared with the HFD group, but the difference is not important. The level of the protein SREBP-1 decreased, and HDF? 1.6KGE group compared to HFD group (p\0.05) (Fig. 3b). Although these are fixed, levels seem low on HFD? 0.8 KGE group compared to the HFD group, the difference is not significant.

Effect of KGE on plasma TG levels after oral administration of lipid emulsion

Effect of KGE on plasma TG levels after oral administration The administration of a lipid emulsion is shown in 4 hours after the administration of the dose of 1000 mg/kg KGE, mean plasma TG level was downloaded more in the control group (p\0.05).
Effect of KGE on plasma TG levels after oral administration of lipid emulsions. After 16 h of fasting, the mice were 0.5 ml of lipid emulsion is given orally with or without KGE. Plasma TG levels were measured as described in therein “Objects and methods” section. The data is presented in mean ± SEM (n = 8). *p\0.05 vs this group is treated with lipids emulsion
 

Effects of KGE on body weight and food intake review 

The effect of KGE on muscle mass and diet Acceptance rates is shown in Table 2. After 8 weeks, The muscle mass in the HFD group is very important, higher than that of the LFD group (p\0.005). No, the weight is greatly reduced, and HDF? 1.6KGE group compared to HFD group (p\0.05). An HFD? One 0.8KGE, and Weight gain tends to be lower on a HFD one, although the difference is not essential. The consumption rate of the LFD group is higher than that of the HFD group (p\0.05), but there are no significant differences in food consumption between HFD and HFD? One KGE.

What Effect of Korean Gingseng?

Dietary fat is one of the most significant environmental factors associated with obesity and chronic diseases such as high blood pressure, diabetes, and hyperlipidemia. For 1000 years, Ginseng is used in herbal medicine and in general tonics to promote health in Eastern societies. This study investigated the anti-obesity effect of KGE on HFD-induced obesity. It has been shown before that HFD is a good strategy to induce obesity. HFD thus leads to an increase in body weight, adipose tissue weight, and hyperlipidemia in animals. Weight loss happens when fat mass decreases due to a reduction in adipocyte differentiation or by reducing adipocyte size. In our study, we found such as body weight, WAT weight, adipocyte size, and plasma TG decreased internal HDF? One 1.6KGE, compared to HFD one, without changing the diet. Inside HDF? Group 0.8KGE, only plasma TG level was downloaded to reduce without changes in the body weight gain or WAT weight. These results are suggestive, and KGE exhibits anti-obesity effects and a hyperlipidemia effect on HFD-induced obesity. And they are consistent with previous reports that Supplementation with ginseng extracts and ginsenosides has anti-obesity and hyperlipidemia effects in obese animals and HFD-induced obesity in type 2 diabetics. Animals, although they do not show resistance to diabetes impact and other reports. We hope that the difference is caused by differences in dietary fat, diet time, experimental species, and aspects of ginseng removal.
Does this observation suggest that the decreased plasma leptin levels in the HFD ? 1.6KGE group may be attributable to reductions in adipose tissue. However, the plasma adiponectin levels were not significantly different between the HFD and HFD ? KGE groups.
Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978305/pdf/10616_2010_Article_9288.pdf

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